Epifisis is a heavy metal band from Medellín, Colombia, formed in 2020 and rooted in the sounds of '70s and '80s heavy metal and hard rock. The band released their debut EP "6402 Sin Futuro" in 2021, a three-track release that deals with themes of social protest, violence, and society. They operate independently and are listed on Metal Archives under the genre Heavy Metal.

Epitafio is a death metal band from Maracay, Venezuela, that emerged in 2016. Their debut release, the digital EP III Operis Tertium (2016), delivers four tracks of punishing, riff-driven death metal with Latin-language track titles reflecting dark and hellish themes. The band operates independently out of the Aragua state metal underground.

Epochal is a progressive/post-metal band from Buenos Aires founded in 2013 by guitarists Daniel Bermúdez and Gustavo Cirigliano. The band recorded their debut album Awakening in late 2015 and early 2016 with drummer Tulio Salvatierra, releasing it in 2016.

Equidnos is a Black/Doom Metal band from Quito, Ecuador rooted in occultist themes. The project released its debut full-length, "Una larga noche de nekromancia 'Kuddesiell Konsinnatio Korporis'", in 2019 through Wolfgang Records, followed by the EP "Instrumentos para medir el viento" in 2021.

Equilibriumm is a black metal band from Neuquén, Patagonia, Argentina, formed around 2001 with themes drawn from dark poetry, medievalism, and gothic imagery. The band released their debut demo Night's Supremacy in 2002 and performed at the 2004 Death Tour alongside Colombian band Massacre, with members operating under aliases including Suicidal Corpse and Black Flames.

Equinoxem is a symphonic gothic metal band from Buenos Aires whose esoteric and occult lyrical themes are matched by orchestral arrangements and dual clean/harsh vocal interplay. The band released their debut album Prophecies of Soul in March 2011, followed by Nightgenesis in April 2015, the latter featuring Matt Tallón on guitar and harsh vocals alongside Ashe Alder on clean vocals.

Erasy is a sludge/stoner/doom metal band from Feira de Santana, Bahia, Brazil, drawing inspiration from Black Sabbath and the slow, heavy end of the metal spectrum. The band has released three studio albums — The Valley of Dying Stars (2016), Under the Moonlight (2018), and Some Nice Flowers (2020) — through Dopesmoke Heavy Music Productions, and has performed at regional festivals including the Dopesmoke Festival.

Erbio was a neoclassical power metal band from Viedma, Río Negro, Argentina, formed in 2001 with a lineup that included vocalist Matias Martinez, guitarist David Neumann, and keyboardist Jorge Amarilla. The band released one demo, Todos, in 2007 before eventually splitting up.

Ereboros is a death metal band formed in Rio de Janeiro in 2022, built from members with extensive prior touring and recording experience across more than 50 countries. The band released their debut self-titled EP in 2023, recorded at Tellus Studio and mixed by Caio Mendonça, and in late 2025 embarked on a 19-date European tour alongside Escarnium and Brutally Deceased.