Despised is a death metal and grindcore duo from Mogi Guaçu, São Paulo, Brazil, formed in 2018, consisting of Alex Roque (guitars, bass, drums) and Rodolfo Carrega (vocals). The band plays brutal, politically driven music and released the album Scorched Earth in 2023 through Kvlt und Kaos Productions.

Despojos is a death metal band from São Paulo, Brazil, formed in 2014. The independent outfit operates within São Paulo's underground death metal scene, drawing on themes of death, gore, and horror.

Despot is a black metal project from Belo Horizonte, Minas Gerais, Brazil, formed by multi-instrumentalist Marcelo Murrer alongside drummer Diogo C. The band blends influences from early death and black metal with a modern eclectic approach, and released the EP Death Drive in July 2021, recorded partly at Black Void Studios in Dublin and mixed at LCS Studios in Nova Lima, Brazil.

Desprezível is an active slam and brutal death metal band from Campina Grande do Sul, Paraná, Brazil, formed in 2024. The band plays in the heavy-hitting Brazilian brutal death tradition and has self-released multiple recordings on Bandcamp, including the tracks "Banho Sangrento" and "Café Com Leite."

Destino Eterno is a melodic death metal and metalcore band from Concepción, Chile, formed in 2016. The band debuted the same year with their "Contracorriente" EP, a six-track release featuring songs sung in Spanish that blend melodic death metal riffing with metalcore structures. They are signed to the Vessels Space label.

Destiny Old Die is a doom metal band from Jaboatão dos Guararapes, Pernambuco, Brazil, operating within the greater Recife metropolitan area. Active and listed on Encyclopaedia Metallum, the band contributes to the underground doom metal scene of northeastern Brazil.

Destitution was a brutal death metal and grindcore band from Bauru, São Paulo, Brazil, catalogued on Encyclopaedia Metallum with gore-themed lyrical content. The band has since split up and is counted among the underground extreme metal acts that emerged from the interior of São Paulo state.

Destripated was a death metal band from Peñalolén, Santiago, Chile, whose lineup comprised vocalist Dismember, guitarist NKVD, bassist Speedmax, and drummer Sulfur Radiator. They released a two-track "Demo 2022" in March 2023, recorded at DOUC UC studio, followed by the EP "Crawling Across The Entrails" in April 2024. The band drew on both old-school and modern death metal influences before splitting up.

DestroyTheHumans is an Argentine grindcore band featuring El Podrido on vocals, Walter on guitars and bass, and Marcelo on drums. The band released the split album Hostis Humani Generis in February 2014 on Coche Bomba Records, paired with US grindcore act Dirty Mike & The Boys, contributing four tracks including "Lead Us" and "Anthem of Negativity."